ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate

Base Information

Chemical Name:ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate
CAS No.:949014-40-8
Molecular Formula:C₂₅H₄₀BrNO₆Si
Molecular Weight:558.585
Hs Code.:

Synonyms:ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate

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Chemical Property of ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate

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Technology Process of ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate

There total 5 articles about ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.33%

: 1171823-92-9
(S)-ethyl 3-(1-hydroxy-3-methylbutan-2-ylamino)-2-(5-bromo-2,4-dimethoxybenzoyl)acrylate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 949014-40-8
ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at -5 - 20 ℃; for 3.75h; Inert atmosphere;

Reference yield:

: 32246-20-1
5-bromo-2,4-dimethoxybenzoic acid

: 949014-40-8
ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; thionyl chloride / toluene / 1 h / 70 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / toluene / 5 h / Inert atmosphere; Reflux

3: tetrahydrofuran / 0.5 h / 20 °C

4: 1H-imidazole / tetrahydrofuran / 3.75 h / -5 - 20 °C / Inert atmosphere

With 1H-imidazole; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

Reference yield:

: 1171823-91-8
ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-(dimethylamino)acrylate

: 949014-40-8
ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-((S)-1-(tert-butyldimethyl-silanyloxymethyl)-2-methylpropylamino)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 20 °C

2: 1H-imidazole / tetrahydrofuran / 3.75 h / -5 - 20 °C / Inert atmosphere

With 1H-imidazole; In tetrahydrofuran;