Technology Process of 3-(2-hydroxy-phenyl)-2-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carbaldehyde
There total 8 articles about 3-(2-hydroxy-phenyl)-2-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N,N-dimethyl-formamide;
With
trichlorophosphate;
for 2h;
Cooling with ice;
Inert atmosphere;
3-(2-hydroxy-phenyl)-2-methyl-2H-isoquinolin-1-one;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 19h;
Inert atmosphere;
With
water; sodium hydroxide;
In
N,N-dimethyl-formamide;
Cooling with ice;
Inert atmosphere;
DOI:10.1016/j.tet.2011.10.053
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / 0 °C / Reflux; Inert atmosphere
2.1: dichloromethane / 0 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 10 h / -78 - -50 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.2: Reflux; Inert atmosphere
5.1: hydrogenchloride / tetrahydrofuran; water / 6 h / Reflux; Inert atmosphere
6.1: trichlorophosphate / 2 h / Cooling with ice; Inert atmosphere
6.2: 19 h / 60 °C / Inert atmosphere
6.3: Cooling with ice; Inert atmosphere
With
hydrogenchloride; n-butyllithium; thionyl chloride; sodium hydride; trichlorophosphate;
In
tetrahydrofuran; hexane; dichloromethane; water;
6.2: Vilsmeier-Haack reaction;
DOI:10.1016/j.tet.2011.10.053
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 10 h / -78 - -50 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
3.2: Reflux; Inert atmosphere
4.1: hydrogenchloride / tetrahydrofuran; water / 6 h / Reflux; Inert atmosphere
5.1: trichlorophosphate / 2 h / Cooling with ice; Inert atmosphere
5.2: 19 h / 60 °C / Inert atmosphere
5.3: Cooling with ice; Inert atmosphere
With
hydrogenchloride; n-butyllithium; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
In
tetrahydrofuran; hexane; dichloromethane; water;
5.2: Vilsmeier-Haack reaction;
DOI:10.1016/j.tet.2011.10.053
