tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate
CAS No.:361336-83-6
Molecular Formula:C₂₆H₃₃F₂N₃O₅S
Molecular Weight:537.628
Hs Code.:

Synonyms:tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 144222-22-0
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

: 619332-99-9
{3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetic acid

: 361336-83-6
tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate

Guidance literature:: {3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetic acid; With PS-carbodiimide; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 0.25h;

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b

Reference yield:

: 361336-80-3
methyl 2-(3-amino-2,6-difluorophenyl)acetate

: 361336-83-6
tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 61 percent / iPr₂NEt / CH₂Cl₂ / 20 h / 20 °C

2.1: 95 percent / aq. NaOH / methanol / 65 °C

3.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH₂Cl₂; dimethylformamide / 0.25 h

3.2: 100 percent / CH₂Cl₂; dimethylformamide

With sodium hydroxide; PS-carbodiimide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b

Reference yield:

: 85068-28-6
2,6-difluorophenylacetic acid

: 361336-83-6
tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 91 percent / HNO₃ / methanol / 0.25 h / -10 °C

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

3.1: 5.47 g / pyridine / CH₂Cl₂ / 20 °C

4.1: 68 percent / Fe; glacial acetic acid / 80 °C

5.1: 61 percent / iPr₂NEt / CH₂Cl₂ / 20 h / 20 °C

6.1: 95 percent / aq. NaOH / methanol / 65 °C

7.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH₂Cl₂; dimethylformamide / 0.25 h

7.2: 100 percent / CH₂Cl₂; dimethylformamide

With pyridine; sodium hydroxide; PS-carbodiimide; oxalyl dichloride; nitric acid; iron; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b