(E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate

Base Information

Chemical Name:(E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate
CAS No.:1444002-79-2
Molecular Formula:C₂₈H₂₈O₈
Molecular Weight:492.526
Hs Code.:

Synonyms:(E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate

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Chemical Property of (E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate

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Technology Process of (E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate

There total 4 articles about (E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1444002-65-6
C₂₃H₂₄O₆

: 105-53-3
diethyl malonate

: 1444002-79-2
(E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate

Guidance literature:: With piperidine; In ethanol; for 0.5h; regioselective reaction; Reflux;
DOI:10.1016/j.ejmech.2013.04.026

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 1444002-79-2
(E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 4 h / 90 °C

2: hydrogenchloride / 1,4-dioxane / Reflux

3: piperidine / ethanol / 0.5 h / Reflux

With piperidine; hydrogenchloride; potassium carbonate; In 1,4-dioxane; ethanol; acetonitrile; 3: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2013.04.026

Reference yield:

: 95-48-7,77504-84-8
ortho-cresol

: 1444002-79-2
(E)-ethyl 6-(3-(4-(4-ethoxy-4-oxobutoxy) phenyl)-3-oxoprop-1-enyl)-8-methyl-2-oxo-2H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 3 h / 120 °C

1.2: 2 h / 90 - 100 °C

2.1: hydrogenchloride / 1,4-dioxane / Reflux

3.1: piperidine / ethanol / 0.5 h / Reflux

With piperidine; hydrogenchloride; In 1,4-dioxane; ethanol; trifluoroacetic acid; 1.1: |Duff Aldehyde Synthesis / 1.2: |Duff Aldehyde Synthesis / 3.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2013.04.026