(±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

Base Information

Chemical Name:(±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole
CAS No.:1170950-07-8
Molecular Formula:C₁₆H₂₀N₂O₆
Molecular Weight:336.345
Hs Code.:

Synonyms:(±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

Suppliers and Price of (±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

There total 5 articles about (±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1170949-99-1
4-acetamido-2,6-dimethyl-5-iodo-3-nitroanisole

: 21433-93-2
(±)-2-methyl-but-3-yne-1,2-diol

: 1170950-07-8
(±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

Guidance literature:: 4-acetamido-2,6-dimethyl-5-iodo-3-nitroanisole; (±)-2-methyl-but-3-yne-1,2-diol; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; for 0.666667h;

With copper(l) iodide; In tetrahydrofuran; for 24h; Reflux;
DOI:10.3987/COM-15-S(T)52

Reference yield:

: 1004-66-6
2-methoxy-1,3-dimethylbenzene

: 1170950-07-8
(±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; nitric acid / water / 0 - 65 °C

2.1: palladium 10% on activated carbon / cyclohexane; ethanol / 14 h / 80 °C

3.1: triethylamine / tetrahydrofuran / 14 h / 0 - 20 °C

4.1: N-iodo-succinimide; acetic acid / 1.5 h / Reflux

5.1: acetic acid; nitric acid / water / 5 h / 65 °C

6.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.67 h

6.2: 24 h / Reflux

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; nitric acid; acetic acid; triethylamine; In tetrahydrofuran; ethanol; cyclohexane; water; 6.1: |Sonogashira Cross-Coupling / 6.2: |Sonogashira Cross-Coupling;
DOI:10.3987/COM-15-S(T)52

Reference yield:

: 1170949-96-8
4-acetamido-2,6-dimethyl-5-iodoanisole

: 1170950-07-8
(±)-4-acetamido-2,6-dimethyl-5-[3’,4’-dihydroxy-3’-methylbut-1’-yn-1’-yl]-3-nitroanisole

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; nitric acid / water / 5 h / 65 °C

2.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.67 h

2.2: 24 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; nitric acid; acetic acid; triethylamine; In tetrahydrofuran; water; 2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling;
DOI:10.3987/COM-15-S(T)52