((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile

Base Information

Chemical Name:((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile
CAS No.:1196060-26-0
Molecular Formula:C₂₀H₁₆Cl₂N₄O₂
Molecular Weight:417.268
Hs Code.:

Synonyms:((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile

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Chemical Property of ((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile

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Technology Process of ((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile

There total 1 articles about ((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1196060-25-9
(5S,9R)-tert-butyl 9-(4-([14C]-cyano)-phenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylate

: 1196060-26-0
((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile

Guidance literature:: (5S,9R)-tert-butyl 9-(4-([14C]-cyano)-phenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With sodium hydrogencarbonate; In dichloromethane; pH=8 - 9;
DOI:10.1002/jlcr.1596

Reference yield: 62.0%

: 1196060-26-0
((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile

: 89324-44-7
3-carboxy-thiophene-5-carboxaldehyde

: 1196060-27-1
5-(((5S,9R)-9-(4-([14C]-cyano)phenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)methyl)-thiophene-3-carboxylic acid

Guidance literature:: ((5S,9R)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-9-yl)benzo-[14C]nitrile; 3-carboxy-thiophene-5-carboxaldehyde; With sodium sulfate; In 1,2-dichloro-ethane; for 20h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
DOI:10.1002/jlcr.1596