4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL

Base Information

• Chemical Name: 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL
• CAS No.: 163008-86-4
• Molecular Formula: C4H6N2OS
• Molecular Weight: 130.17
• Hs Code.: 2934999090
• Mol file: 163008-86-4.mol

Synonyms:4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL;(4-Methyl-1,2,3-thiadiazol-5-yl)methanol;5-(Hydroxymethyl)-4-methyl-1,2,3-thiadiazole;(4-methyl-1,2,3-thiadiazol-5-yl)methanol(SALTDATA: FREE)

Chemical Property of 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 261.481 °C at 760 mmHg
• Flash Point: 111.94 °C
• PSA: 74.25000
• Density: 1.364 g/cm³
• LogP: 0.33880
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(4-Methyl-1,2,3-thiadiazol-5-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL

There total 3 articles about 4-METHYL-1,2,3-THIADIAZOLE-5-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester (18212-20-9) → 5-hydroxymethyl-4-methyl-1,2,3-thiadiazole (163008-86-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; Cooling with ice;

DOI:10.1016/j.cclet.2017.02.002

Reference yield: 89.6%

→ 5-hydroxymethyl-4-methyl-1,2,3-thiadiazole (163008-86-4)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 0 - 25 ℃; for 5h;

Reference yield:

methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate (183298-93-3) → 5-hydroxymethyl-4-methyl-1,2,3-thiadiazole (163008-86-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 15h;

upstream raw materials:

4-methyl-1,2,3-thiadiazole-5-carboxylic acid ethyl ester

methyl 4-methyl-1,2,3-thiadiazole-5-carboxylate

Downstream raw materials:

4-methyl-1,2,3-thiadiazole-5-carbaldehyde

Refernces

• 1、 Chen, Lai,Zhu, Yu-Jie,Fan, Zhi-Jin,Guo, Xiao-Feng,Zhang, Zhi-Ming,Xu, Jing-Hua,Song, Ying-Qi,Yurievich, Morzherin Y.,Belskaya, Nataliya P.,Bakulev, Vasiliy A.. "Synthesis of 1,2,3-thiadiazole and thiazole-based strobilurins as potent fungicide candidates". . p. 745 - 751. Retrieved 2017/02/10.
• 2、 Wang, Shou-Xin,Fang, Zhen,Fan, Zhi-Jin,Wang, Dun,Li, Yue-Dong,Ji, Xiao-Tian,Hua, Xue-Wen,Huang, Yun,Kalinina, Tatiana A.,Bakulev, Vasiliy A.,Morzherin, Yury Yu.. "Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity". . p. 889 - 892. Retrieved 2013/09/24.