(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Base Information

Chemical Name:(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid
CAS No.:1303606-44-1
Molecular Formula:C₂HF₃O₂*C₂₈H₃₂Cl₂FN₃O₃
Molecular Weight:662.509
Hs Code.:

(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Synonyms:(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Suppliers and Price of (2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

There total 7 articles about (2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303609-27-9
C₄₈H₅₈Cl₂FN₃O₄Si

: 1303606-44-1
(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; for 1h;

Reference yield:

: 1303609-23-5
benzyl 3-(tert-butyldimethylsilyloxy)-3-methylcyclobutylcarbamate

: 1303606-44-1
(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; sodium hydrogencarbonate / palladium on activated charcoal / isopropyl alcohol / 1 h / 760.05 Torr

2.1: tetrahydrofuran

2.2: 0.5 h

3.1: hydrogenchloride / methanol; water / 1 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; isopropyl alcohol;

Reference yield:

: 1303609-22-4
3-[tert-butyl(dimethyl)silyl]oxy-3-methylcyclobutanecarboxylic acid

: 1303606-44-1
(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloroformic acid ethyl ester; triethylamine / acetone / 0.5 h / 0 °C

1.2: 0.33 h / 0 °C

1.3: 2 h / 80 °C

2.1: hydrogen; sodium hydrogencarbonate / palladium on activated charcoal / isopropyl alcohol / 1 h / 760.05 Torr

3.1: tetrahydrofuran

3.2: 0.5 h

4.1: hydrogenchloride / methanol; water / 1 h / 20 °C

With hydrogenchloride; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; isopropyl alcohol; acetone;