2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydro-

Base Information

• Chemical Name: 2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydro-
• CAS No.: 897365-76-3
• Molecular Formula: C15H8Cl2FNO
• Molecular Weight: 308.139
• Hs Code.: 2933790090
• Mol file: 897365-76-3.mol

Synonyms:2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydro-

Chemical Property of 2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydro-

Chemical Property:

• PSA: 32.59000
• LogP: 4.71030
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

(Z)-6-Chloro-3-(3-chloro-2-fluorobenzylidene)indolin-2-one 95% ^*data from reagent suppliers

Safty Information:

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Technology Process of 2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydro-

There total 5 articles about 2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

→ (3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one (897365-76-3)

Guidance literature:

Reference yield: 94.0%

6-chloro-2-oxindole (56341-37-8) + 2-fluoro-3-chlorobenzaldehyde (85070-48-0) → (3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one (897365-76-3)

Guidance literature:

With piperidine; In ethanol; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo302460d

Reference yield: 89.0%

6-chloro-2-oxoindole (1174006-94-0) + 2-fluoro-3-chlorobenzaldehyde (85070-48-0) → (3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one (897365-76-3)

Guidance literature:

With piperidine; In methanol; at 50 ℃; for 3h;

upstream raw materials:

5-chloro-1,3-dihydro-2H-inden-2-one

2-fluoro-3-chlorobenzaldehyde

6-chloro-2-oxindole

6-chloro-2-oxoindole

Downstream raw materials:

(3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione

(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

C₄₈H₅₈Cl₂FN₃O₄Si

(2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid

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