tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Base Information

Chemical Name:tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate
CAS No.:1366063-59-3
Molecular Formula:C₁₇H₂₂F₃N₃O₄
Molecular Weight:389.375
Hs Code.:

Synonyms:tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

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Chemical Property of tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

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Technology Process of tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

There total 1 articles about tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 64017-81-8
3-aminopropanamide hydrochloride

: 146621-92-3
2-{[(tert-butoxy)carbonyl]amino}-2-[3-(trifluoromethyl)phenyl]acetic acid

: 1366063-59-3
tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: 2-{[(tert-butoxy)carbonyl]amino}-2-[3-(trifluoromethyl)phenyl]acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

3-aminopropanamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1366063-59-3
tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

: 1366063-67-3
tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

: 1366063-65-1
tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

Guidance literature:: With stationary phase Daicel Chiralpak AD-H, 10 nm, column: 250 mm×20 mm; In 2-Methylpentane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 1366063-59-3
tert-butyl {2-[(3-amino-3-oxopropyl)amino]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}carbamate

: 1366062-01-2
N³-{[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino][3-(trifluoromethyl)phenyl]acetyl}-beta-alaninamide

Guidance literature:: Multi-step reaction with 3 steps

1: stationary phase Daicel Chiralpak AD-H, 10 nm, column: 250 mm×20 mm / 2-Methylpentane; isopropyl alcohol / Resolution of racemate

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 2-Methylpentane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;