1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine

Base Information

• Chemical Name: 1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine
• CAS No.: 219724-73-9
• Molecular Formula: C₃₀H₃₇N₅O₅Si
• Molecular Weight: 575.74

Synonyms:1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine

Chemical Property of 1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine

Chemical Property:

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Technology Process of 1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine

There total 8 articles about 1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-benzyl-2-N-(N,N-dibenzylformamidino)-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine → 1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine (219724-73-9)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; water; tert-butyl alcohol; at 45 ℃; for 6h;

DOI:10.1080/07328319908044869

Reference yield: 87.0%

N'-{1-benzyl-9-[6-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-N,N-dimethyl-formamidine → 1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine (219724-73-9)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 3h;

DOI:10.1021/jo980099g

Reference yield: 70.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 1-benzyl-9-(2',3'-O-benzylidene-β-D-ribofuranosyl)guanine (214918-86-2) → 1-benzyl-9-(5-O-t-butyldimethylsilyl-2,3-O-benzylidene-β-D-ribofuranosyl)-guanine (219724-73-9)

Guidance literature:

With dmap;

DOI:10.1016/S0040-4039(98)02074-7

upstream raw materials:

tert-butyldimethylsilyl chloride

1-benzyl-9-(2',3'-O-benzylidene-β-D-ribofuranosyl)guanine

benzyl alcohol

benzaldehyde

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