7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

Base Information

Chemical Name:7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane
CAS No.:916728-16-0
Molecular Formula:C₃₀H₄₁NO₆
Molecular Weight:511.659
Hs Code.:

Synonyms:7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

There total 3 articles about 7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

: 77-76-9
2,2-dimethoxy-propane

: 916728-16-0
7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

: 7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

Guidance literature:: With toluene-4-sulfonic acid; In dimethyl sulfoxide; at 20 ℃; for 48h;
DOI:10.1002/anie.200602569

Reference yield:

: 916728-14-8
2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinane-4-carboxylic acid methyl ester

: 916728-16-0
7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / KHMDS; 3-phenyl-2-(p-toluenesulfonyl)-oxaziridine / tetrahydrofuran / 2.5 h / cooling

2: 97 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / cooling

3: p-toluenesulfonic acid / dimethylsulfoxide / 48 h / 20 °C

With lithium aluminium tetrahydride; potassium hexamethylsilazane; toluene-4-sulfonic acid; 2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1002/anie.200602569

Reference yield:

: 4-hydroxy-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinane-4-carboxylic acid methyl ester

: 916728-16-0
7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / cooling

2: p-toluenesulfonic acid / dimethylsulfoxide / 48 h / 20 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1002/anie.200602569