((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane
CAS No.:201275-42-5
Molecular Formula:C₁₈H₃₀O₃Si
Molecular Weight:322.52
Hs Code.:

Synonyms:((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of ((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane

There total 10 articles about ((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 201275-56-1
[(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

: 201275-42-5
((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; methanol; at -78 ℃;
DOI:10.1016/S0040-4039(97)10500-7

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 201275-42-5
((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 10 steps

1: NaH / tetrahydrofuran

2: HCl / methanol

3: PPTs

4: 1.) TMSCl; 2.) K₂CO₃ / 1.) CH₂Cl₂; 2.) MeOH

5: CuCN / tetrahydrofuran / -78 °C

6: KHMDS / tetrahydrofuran / -78 °C

7: IBr / toluene / -78 °C

8: K₂CO₃ / methanol

9: 76 percent / TMEDA

10: 95 percent / t-BuLi / tetrahydrofuran; methanol / -78 °C

With hydrogenchloride; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; pyridinium p-toluenesulfonate; iodine(I) bromide; potassium hexamethylsilazane; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/S0040-4039(97)10500-7

Reference yield:

: 201275-44-7
(R)-2-(4-bromo-benzyloxymethyl)-oxirane

: 201275-42-5
((R)-1-Benzyloxymethyl-2-(S)-oxiranyl-ethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: CuCN / tetrahydrofuran / -78 °C

2: KHMDS / tetrahydrofuran / -78 °C

3: IBr / toluene / -78 °C

4: K₂CO₃ / methanol

5: 76 percent / TMEDA

6: 95 percent / t-BuLi / tetrahydrofuran; methanol / -78 °C

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; iodine(I) bromide; potassium hexamethylsilazane; potassium carbonate; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/S0040-4039(97)10500-7