[(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane
CAS No.:201275-56-1
Molecular Formula:C₁₈H₂₉BrO₃Si
Molecular Weight:401.416
Hs Code.:

Synonyms:[(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

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Technology Process of [(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

There total 9 articles about [(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 201275-47-0
(R)-1-(4-Bromo-benzyloxy)-3-(S)-oxiranyl-propan-2-ol

: 201275-56-1
[(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2009.04.001

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 201275-56-1
[(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 9 steps

1: NaH / tetrahydrofuran

2: HCl / methanol

3: PPTs

4: 1.) TMSCl; 2.) K₂CO₃ / 1.) CH₂Cl₂; 2.) MeOH

5: CuCN / tetrahydrofuran / -78 °C

6: KHMDS / tetrahydrofuran / -78 °C

7: IBr / toluene / -78 °C

8: K₂CO₃ / methanol

9: 76 percent / TMEDA

With hydrogenchloride; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; pyridinium p-toluenesulfonate; iodine(I) bromide; potassium hexamethylsilazane; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/S0040-4039(97)10500-7

Reference yield:

: 201275-44-7
(R)-2-(4-bromo-benzyloxymethyl)-oxirane

: 201275-56-1
[(R)-1-(4-Bromo-benzyloxymethyl)-2-(S)-oxiranyl-ethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: CuCN / tetrahydrofuran / -78 °C

2: KHMDS / tetrahydrofuran / -78 °C

3: IBr / toluene / -78 °C

4: K₂CO₃ / methanol

5: 76 percent / TMEDA

With N,N,N,N,-tetramethylethylenediamine; iodine(I) bromide; potassium hexamethylsilazane; potassium carbonate; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/S0040-4039(97)10500-7