5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

Base Information

Chemical Name:5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide
CAS No.:908020-38-2
Molecular Formula:C₃₈H₅₆N₆O₇S
Molecular Weight:740.965
Hs Code.:

5-(2-oxo-hexahydro-thieno[3,4-<i>d</i>]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

Synonyms:5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

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Chemical Property of 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

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Technology Process of 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

There total 4 articles about 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 908020-36-0
[(4-benzoyl-benzyl)-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-amino]-acetic acid methyl ester

: 107-15-3,85404-18-8
ethylenediamine

: 58-85-5,22879-79-4
biotin

: 908020-38-2
5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

Guidance literature:: [(4-benzoyl-benzyl)-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-amino]-acetic acid methyl ester; With trifluoroacetic acid; In dichloromethane; for 17h;

biotin; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; for 48h;

ethylenediamine; for 2h;
DOI:10.1002/anie.200600743

Reference yield:

: 908020-34-8
[3-(2-{2-[3-(4-benzoyl-benzylamino)-propoxy]-ethoxy}-ethoxy)-propyl]-carbamic acid tert-butyl ester

: 908020-38-2
5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 17 h

2.1: trifluoroacetic acid / CH₂Cl₂ / 17 h

2.2: 1-hydroxy-1H-benzotriazole; N,N-diisopropylethylamine; diisopropylcarbodiimide / dimethylformamide / 48 h

2.3: 70 percent / 2 h

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/anie.200600743

Reference yield:

: 32752-54-8
4-(bromomethyl)benzophenone

: 908020-38-2
5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid {3-[2-(2-{3-[[(2-amino-ethylcarbamoyl)-methyl]-(4-benzoyl-benzyl)-amino]-propoxy}-ethoxy)-ethoxy]-propyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / K₂CO₃ / acetonitrile; CH₂Cl₂ / 17 h

2.1: 97 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 17 h

3.1: trifluoroacetic acid / CH₂Cl₂ / 17 h

3.2: 1-hydroxy-1H-benzotriazole; N,N-diisopropylethylamine; diisopropylcarbodiimide / dimethylformamide / 48 h

3.3: 70 percent / 2 h

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1002/anie.200600743