tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate
CAS No.:1301610-91-2
Molecular Formula:C₂₈H₂₉N₃O₃S
Molecular Weight:487.623
Hs Code.:

Synonyms:tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

There total 5 articles about tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1301610-90-1
tert-butyl (1-(4-(5-bromo-2-(methylthio)furo[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

: 98-80-6
phenylboronic acid

: 1301610-91-2
tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 0.333333h; Microwave irradiation; Sealed tube;

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1301610-91-2
tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: diisopropylamine / copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 20 - 80 °C / Inert atmosphere

2: potassium carbonate; methanol / 1 h

3: diisopropylamine / copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4: N-Bromosuccinimide / acetonitrile / 16 h / 60 °C / Inert atmosphere

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.33 h / 120 °C / Microwave irradiation; Sealed tube

With methanol; potassium phosphate; N-Bromosuccinimide; potassium carbonate; diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1301610-33-2
tert-butyl 1-(4-ethynylphenyl)cyclobutylcarbamate

: 1301610-91-2
tert-butyl (1-(4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylamine / copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2: N-Bromosuccinimide / acetonitrile / 16 h / 60 °C / Inert atmosphere

3: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.33 h / 120 °C / Microwave irradiation; Sealed tube

With potassium phosphate; N-Bromosuccinimide; diisopropylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; acetonitrile;