1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole

Base Information

Chemical Name:1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole
CAS No.:194163-28-5
Molecular Formula:C₃₃H₄₂N₂O₆S
Molecular Weight:594.772
Hs Code.:

Synonyms:1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole

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Chemical Property of 1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole

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Technology Process of 1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole

There total 6 articles about 1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 98-59-9
p-toluenesulfonyl chloride

: 1027280-78-9
2,2-Dimethyl-propionic acid 6-[(2,2-diethoxy-ethylamino)-methyl]-5,8-dimethyl-9H-carbazol-3-yl ester

: 194163-28-5
1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.chembiol.2018.10.018

Reference yield:

: 18028-57-4
6-methoxy-1,4-dimethyl-9H-carbazole

: 194163-28-5
1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / NaI / acetonitrile / 1 h / Heating

2: 96 percent / phosphorus oxychloride / toluene / 3.5 h / Heating

3: p-TsOH*H₂O / 1.5 h / Heating

4: H₂ / PtO₂ / ethanol / 3.5 h / 760 Torr / Ambient temperature

5: Et₃N / tetrahydrofuran / 18 h / Ambient temperature

With hydrogen; toluene-4-sulfonic acid; triethylamine; sodium iodide; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; ethanol; toluene; acetonitrile;
DOI:10.1248/cpb.45.1156

Reference yield:

: 194163-27-4
3-formyl-1,4-dimethyl-6-pivaloyloxycarbazole

: 194163-28-5
1,4-dimethyl-6-pivaloyloxy-3-(N-tosyl-2,2-diethoxyethylaminomethyl)-9H-carbazole

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH*H₂O / 1.5 h / Heating

2: H₂ / PtO₂ / ethanol / 3.5 h / 760 Torr / Ambient temperature

3: Et₃N / tetrahydrofuran / 18 h / Ambient temperature

With hydrogen; toluene-4-sulfonic acid; triethylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.45.1156