(1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

Base Information

Chemical Name:(1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol
CAS No.:942618-52-2
Molecular Formula:C₄₇H₆₇NO₇Si
Molecular Weight:786.137
Hs Code.:

(1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

Synonyms:(1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

Suppliers and Price of (1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

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Chemical Property of (1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

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Technology Process of (1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

There total 14 articles about (1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942618-32-8
(3S,5S,10S)-3-benzyloxycarbonylamino-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-ene-2,8-dione

: 942618-52-2
(1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / NaBH₄; CeCl₃*7H₂O / propan-2-ol; tetrahydrofuran / 0.67 h / 0 °C

2: 99 percent / mCPBA / CH₂Cl₂ / 24 h / 20 °C

3: 99 percent / pyridine; DMAP / CH₂Cl₂ / 24 h / 0 - 20 °C

4: 94 percent / NaBH₄ / ethanol / 9 h / 0 °C

5: 94 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

6: 83 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

7: 84 percent / mCPBA / CH₂Cl₂ / 70 h / 0 °C

8: H₂; AcOH / Pd(OH)2/C / methanol / 0.5 h / 20 °C / 760.05 Torr

9: 40.2 mg / EDCI; diisopropylethylamine / dimethylformamide / 12 h / 0 - 20 °C

With pyridine; 2,6-dimethylpyridine; dmap; sodium tetrahydroborate; cerium(III) chloride; tetrabutyl ammonium fluoride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo070337k

Reference yield:

: 942618-45-3
(3S,5S,8R,10S)-8-acetoxy-3-benzyloxycarbonylamino-10-triethylsilyloxy-1-oxaspiro[4,5]dec-6-en-2-one

: 942618-52-2
(1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / NaBH₄ / ethanol / 9 h / 0 °C

2: 94 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

3: 83 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

4: 84 percent / mCPBA / CH₂Cl₂ / 70 h / 0 °C

5: H₂; AcOH / Pd(OH)2/C / methanol / 0.5 h / 20 °C / 760.05 Torr

6: 40.2 mg / EDCI; diisopropylethylamine / dimethylformamide / 12 h / 0 - 20 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; tetrabutyl ammonium fluoride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo070337k

Reference yield:

: 942618-48-6
(1S,2'S,4R,6S)-4-acetoxy-1-(2'-benzyloxycarbonylamino-3'-tert-butyldiphenylsilyloxy-propyl)-6-hydroxy-2-cyclohexen-1-ol

: 942618-52-2
(1R,2S,2'S,2''E,3S,4R,4''E,6S,6''E,8''R,10''S,12''E,14''R)-4-acetoxy-2,3-epoxy-6-hydroxy-1-[2'-(8'',10'',12'',14''-tetramethylhexadeca-2'',4'',6'',12''-tetraenoylamino)-3'-tert-butyldiphenylsilyloxy-propyl]-2-cyclohexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / mCPBA / CH₂Cl₂ / 70 h / 0 °C

2: H₂; AcOH / Pd(OH)2/C / methanol / 0.5 h / 20 °C / 760.05 Torr

3: 40.2 mg / EDCI; diisopropylethylamine / dimethylformamide / 12 h / 0 - 20 °C

With hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo070337k