phenyl hydrogen phosphorofluoridate

Base Information

• Chemical Name: phenyl hydrogen phosphorofluoridate
• CAS No.: 3910-11-0
• Molecular Formula: C₆H₆FO₃P
• Molecular Weight: 176.084
• Mol file: 3910-11-0.mol

Synonyms:phenyl hydrogen phosphorofluoridate

Chemical Property of phenyl hydrogen phosphorofluoridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of phenyl hydrogen phosphorofluoridate

There total 4 articles about phenyl hydrogen phosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.2%

sodium phenyl (1H-imidazol-1-yl)phosphonate → phenyl hydrogen phosphorofluoridate (3910-11-0)

Guidance literature:

With tetrabutyl ammonium fluoride; zinc(II) chloride; In tetrahydrofuran; at 60 ℃; for 12h;

DOI:10.1016/j.tetlet.2021.152917

Reference yield:

phosphoric acid monophenyl ester (701-64-4) → phenyl hydrogen phosphorofluoridate (3910-11-0)

Guidance literature:

With 2,4-Dinitrofluorobenzene; triethylamine; In acetonitrile;

Reference yield:

tetrabutyl-ammonium monophenyl phosphate (21151-71-3,21151-72-4) → phenyl hydrogen phosphorofluoridate (3910-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine; 2,2'-dipyridyldisulphide / N,N-dimethyl-formamide / 20 °C

1.2: 2 h / 0 °C

2.1: tetrabutyl ammonium fluoride; zinc(II) chloride / tetrahydrofuran / 12 h / 60 °C

With 2,2'-dipyridyldisulphide; tetrabutyl ammonium fluoride; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2021.152917

upstream raw materials:

phosphoric acid monophenyl ester

tetrabutyl-ammonium monophenyl phosphate