7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

Base Information

Chemical Name:7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one
CAS No.:913976-19-9
Molecular Formula:C₃₈H₅₉NO₈Si
Molecular Weight:685.974
Hs Code.:

Synonyms:7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

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Chemical Property of 7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

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Technology Process of 7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

There total 2 articles about 7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 913976-18-8
6β,9α-dihydroxy-8,13-epoxy-7β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

: 913976-19-9
7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

Guidance literature:: With sodium hydroxide; In diethyl ether; water; acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 105535-46-4
1α-<(tert-butyldimethylsilyl)oxy>-8,13-epoxy-6β,7β,9α-trihydroxylabd-14-en-11-one

: 913976-19-9
7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / DCC; DMAP / dimethylformamide / 16 h

2: 55 percent / NaOH / acetonitrile; diethyl ether; H₂O / 16 h / 20 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 913976-19-9
7β,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-1α-tert-butyldimethylsilyloxy-labd-14-en-11-one

: 7β-acetoxy-1α,9α-dihydroxy-8,13-epoxy-6β-[3-(4-morpholinomethyl)benzoyloxy]-labd-14-en-11-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / DCC; DMAP / ethyl acetate

2: 62.7 percent / Bu₄N⁽¹⁺⁾*F^(1-); molecular sieves 4 Angstroem / tetrahydrofuran / 0.08 h

With dmap; 4 A molecular sieve; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;