(R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Base Information

Chemical Name:(R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate
CAS No.:1344707-54-5
Molecular Formula:C₂HF₃O₂*C₂₆H₂₁F₃N₆O₄
Molecular Weight:652.51
Hs Code.:

(R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Synonyms:(R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

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Chemical Property of (R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

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Technology Process of (R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

There total 10 articles about (R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.9%

: 499770-63-7
1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine

: 1344708-41-3,1344708-42-4,1344708-43-5
(R/S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 76-05-1
trifluoroacetic acid

: 1344707-54-5
(R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Guidance literature:: 1-(1,3-dimethyl-1H-pyrazol-5-yl)methanamine; (R/S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; for 1h;

trifluoroacetic acid; In methanol; water;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1344707-54-5
(R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

3.1: Jones reagent / acetone / 20 °C

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

7.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

7.2: PHENOMENEX_.(R). Luna 5u

With 4-methyl-morpholine; pyridine; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 934-16-7
phenylhydroxamoyl chloride

: 1344707-54-5
(R/S)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 1,2-dichloro-ethane / 20 - 70 °C

2.1: Jones reagent / acetone / 20 °C

3.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 0 °C

6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1 h

6.2: PHENOMENEX_.(R). Luna 5u

With 4-methyl-morpholine; pyridine; Jones reagent; trifluoro-[1,3,5]triazine; water; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;