1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

Base Information

Chemical Name:1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole
CAS No.:848945-13-1
Molecular Formula:C₂₉H₂₉IN₂O₄
Molecular Weight:596.465
Hs Code.:

Synonyms:1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

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Chemical Property of 1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

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Technology Process of 1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

There total 3 articles about 1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 848945-12-0
1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4,5-diiodo-1H-imidazole

: 848945-13-1
1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

Guidance literature:: With ethylmagnesium bromide; In diethyl ether; at 20 ℃; for 3h;
DOI:10.1021/jo048218h

Reference yield:

: 848945-11-9
1-(4,5-diiodoimidazol-3-yl)-β-D-ribofuranose

: 848945-13-1
1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 18 h / 20 °C

2: 80 percent / EtMgBr / diethyl ether / 3 h / 20 °C

With ethylmagnesium bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo048218h

Reference yield:

: 848945-10-8
Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(4,5-diiodo-imidazol-1-yl)-tetrahydro-furan-3-yl ester

: 848945-13-1
1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: 52.8 g / ammonium hydroxide / ethanol / 18 h / 20 °C

2: 80 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 18 h / 20 °C

3: 80 percent / EtMgBr / diethyl ether / 3 h / 20 °C

With ammonium hydroxide; ethylmagnesium bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/jo048218h