2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine

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Chemical Name:2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine
CAS No.:848945-14-2
Molecular Formula:C₄₇H₄₄N₄O₆
Molecular Weight:760.89
Hs Code.:

Synonyms:2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine

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Chemical Property of 2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine

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Technology Process of 2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine

There total 6 articles about 2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 848945-13-1
1-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-iodo-1H-imidazole

: 70523-24-9
5-(dihydroxyboryl)-2,4-bis(benzyloxy)pyrimidine

: 848945-14-2
2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 4h; Heating;
DOI:10.1021/jo048218h

Reference yield:

: 848945-11-9
1-(4,5-diiodoimidazol-3-yl)-β-D-ribofuranose

: 848945-14-2
2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 18 h / 20 °C

2: 80 percent / EtMgBr / diethyl ether / 3 h / 20 °C

3: 70 percent / NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 4 h / Heating

With ethylmagnesium bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; water; 3: Suzuki coupling;
DOI:10.1021/jo048218h

Reference yield:

: 848945-10-8
Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(4,5-diiodo-imidazol-1-yl)-tetrahydro-furan-3-yl ester

: 848945-14-2
2,4-Bis-benzyloxy-5-[1-((2R,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-imidazol-4-yl]-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 52.8 g / ammonium hydroxide / ethanol / 18 h / 20 °C

2: 80 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 18 h / 20 °C

3: 80 percent / EtMgBr / diethyl ether / 3 h / 20 °C

4: 70 percent / NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 4 h / Heating

With ammonium hydroxide; ethylmagnesium bromide; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; water; 4: Suzuki coupling;
DOI:10.1021/jo048218h