Technology Process of 1-benzoxy-2,6-dimethoxy-3-(hydroxymethyl)-8-(methoxymethoxy)naphthalene
There total 5 articles about 1-benzoxy-2,6-dimethoxy-3-(hydroxymethyl)-8-(methoxymethoxy)naphthalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
toluene;
at -78 ℃;
for 0.5h;
DOI:10.1021/ja00149a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 63 percent / CH2Cl2 / 1 h / 0 °C
2: 2.) K2HPO3-deactivated silica gel / 1.) 0 deg C, 2 d, 2.) EtOAc, 1 h
3: 47 percent / K2CO3, n-Bu4NI / dimethylsulfoxide / 72 h / 28 °C
4: 95 percent / i-Bu2AlH / toluene / 0.5 h / -78 °C
With
K2HPO3-deactivated silica gel; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate;
In
dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja00149a012
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 47 percent / K2CO3, n-Bu4NI / dimethylsulfoxide / 72 h / 28 °C
2: 95 percent / i-Bu2AlH / toluene / 0.5 h / -78 °C
With
tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate;
In
dimethyl sulfoxide; toluene;
DOI:10.1021/ja00149a012
