6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile

Base Information

Chemical Name:6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile
CAS No.:1456802-05-3
Molecular Formula:C₂₈H₁₈ClN₅O₂
Molecular Weight:491.936
Hs Code.:

Synonyms:6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile

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Chemical Property of 6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile

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Technology Process of 6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile

There total 5 articles about 6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1456802-31-5
6-(1H-benzo[d]imidazol-2-yl)-2-(benzylideneamino)-4-(3-hydroxyphenyl)nicotinonitrile

: 79-04-9
chloroacetyl chloride

: 1456802-05-3
6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile

Guidance literature:: With triethylamine; In 1,4-dioxane; at 0 ℃; for 9h; Reflux;
DOI:10.1007/s00044-013-0775-1

Reference yield:

: 20224-08-2
C₁₆H₁₂N₂O₂

: 1456802-05-3
6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 10 h / Reflux

2: zinc(II) chloride / 1,4-dioxane / 6 h / Reflux

3: triethylamine / 1,4-dioxane / 9 h / 0 °C / Reflux

With ammonium acetate; triethylamine; zinc(II) chloride; In 1,4-dioxane; ethanol;
DOI:10.1007/s00044-013-0775-1

Reference yield:

: 1456802-18-8
2-amino-6-(1H-benzo[d]imidazol-2-yl)-4-(3-hydroxyphenyl)nicotinonitrile

: 1456802-05-3
6-(1H-benzo[d]imidazol-2-yl)-2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(3-hydroxyphenyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride / 1,4-dioxane / 6 h / Reflux

2: triethylamine / 1,4-dioxane / 9 h / 0 °C / Reflux

With triethylamine; zinc(II) chloride; In 1,4-dioxane;
DOI:10.1007/s00044-013-0775-1