(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid

Base Information

• Chemical Name: (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid
• CAS No.: 192052-55-4
• Molecular Formula: C₂₉H₄₅N₃O₉
• Molecular Weight: 579.691
• Mol file: 192052-55-4.mol

Synonyms:(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid

Chemical Property of (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid

There total 3 articles about (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester (192052-54-3) → (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid (192052-55-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1002/hlca.19970800304

Reference yield:

(S)-5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate (32886-55-8) → (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid (192052-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / (ⁱPr)2EtN / dimethylformamide / 23 h / Ambient temperature

2: 99.5 percent / H₂ / 10percent Pd/C / ethanol; H₂O / 4 h / 760 Torr / Ambient temperature

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19970800304

Reference yield:

N-L-tyrosyl-L-leucine benzyl ester; hydrochloride (114658-52-5) → (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid (192052-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / (ⁱPr)2EtN / dimethylformamide / 23 h / Ambient temperature

2: 99.5 percent / H₂ / 10percent Pd/C / ethanol; H₂O / 4 h / 760 Torr / Ambient temperature

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19970800304

upstream raw materials:

(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester

(S)-5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate

N-L-tyrosyl-L-leucine benzyl ester; hydrochloride

Downstream raw materials:

(S)-4-tert-Butoxycarbonylamino-4-{(S)-2-(4-hydroxy-phenyl)-1-[(S)-3-methyl-1-(morpholine-4-carbonyl)-butylcarbamoyl]-ethylcarbamoyl}-butyric acid tert-butyl ester

Boc-Glu(O^tBu)-Tyr[CO(CH₂)4CO-bzoc⁶A(=CMe₂)]-Leu-morpholine