(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester
• CAS No.: 192052-54-3
• Molecular Formula: C₃₆H₅₁N₃O₉
• Molecular Weight: 669.816
• Mol file: 192052-54-3.mol

Synonyms:(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester

Chemical Property of (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester

There total 1 articles about (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate (32886-55-8) + N-L-tyrosyl-L-leucine benzyl ester; hydrochloride (114658-52-5) → (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester (192052-54-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 23h; Ambient temperature;

DOI:10.1002/hlca.19970800304

Reference yield: 99.5%

(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester (192052-54-3) → (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid (192052-55-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; for 4h; under 760 Torr; Ambient temperature;

DOI:10.1002/hlca.19970800304

Reference yield: 56.0%

(tert-butyl)dimethylsilyl 2-[(tert-butyl)dimethylsilyloxy]-4-(chlorosulfonyl)benzoate + (S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid benzyl ester (192052-54-3) → 4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid (192052-62-3) + C49H69N3O14SSi

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 20h; Ambient temperature; 1.) -3 deg C;

DOI:10.1002/hlca.19970800304

upstream raw materials:

(S)-5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)pentanedioate

N-L-tyrosyl-L-leucine benzyl ester; hydrochloride

Downstream raw materials:

4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-benzoic acid

4-{4-[(S)-2-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-2-((S)-4-tert-butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-ethyl]-phenoxysulfonyl}-2-hydroxy-benzoic acid

(S)-2-[(S)-2-((S)-4-tert-Butoxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoic acid

(S)-4-tert-Butoxycarbonylamino-4-{(S)-2-(4-hydroxy-phenyl)-1-[(S)-3-methyl-1-(morpholine-4-carbonyl)-butylcarbamoyl]-ethylcarbamoyl}-butyric acid tert-butyl ester