(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Base Information

Chemical Name:(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester
CAS No.:312326-52-6
Molecular Formula:C₃₉H₅₅O₉PSi
Molecular Weight:726.92
Hs Code.:

(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Synonyms:(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

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Chemical Property of (Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

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Technology Process of (Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

There total 8 articles about (Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3095-95-2
diethylphosphonoacetic acid

: 312326-51-5
(2R,3R)-1-[2-(2-Benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-butan-2-ol

: 312326-52-6
(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 5694-95-1
2-(2-(2-hydroxyethyl)-1,3-dioxolan-2-yl)ethanol

: 312326-52-6
(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran

1.2: 76 percent / Bu₄NI

2.1: 97 percent / Dess-Martin periodinane

3.1: 83 percent / Bu₂BOTf / CH₂Cl₂

4.1: 85 percent / LiBH₄ / tetrahydrofuran

5.1: 99 percent / imidazole / dimethylformamide

6.1: 84 percent / EDC / CH₂Cl₂

With 1H-imidazole; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sodium hydride; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 2.1: Oxidation / 3.1: Metallation / 4.1: Reduction / 5.1: Substitution / 6.1: Acylation;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 6506-31-6
dimethyl acetonedicarboxylate ethylene ketal

: 312326-52-6
(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / LiAlH₄ / tetrahydrofuran

2.1: NaH / tetrahydrofuran

2.2: 76 percent / Bu₄NI

3.1: 97 percent / Dess-Martin periodinane

4.1: 83 percent / Bu₂BOTf / CH₂Cl₂

5.1: 85 percent / LiBH₄ / tetrahydrofuran

6.1: 99 percent / imidazole / dimethylformamide

7.1: 84 percent / EDC / CH₂Cl₂

With 1H-imidazole; lithium aluminium tetrahydride; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; sodium hydride; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: Metallation / 3.1: Oxidation / 4.1: Metallation / 5.1: Reduction / 6.1: Substitution / 7.1: Acylation;
DOI:10.1016/S0040-4039(00)01337-X