(R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one

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Chemical Name:(R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one
CAS No.:312326-54-8
Molecular Formula:C₃₃H₄₀O₄Si
Molecular Weight:528.764
Hs Code.:

Synonyms:(R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one

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Chemical Property of (R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one

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Technology Process of (R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one

There total 10 articles about (R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 312326-53-7
(Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

: 312326-54-8
(R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 5694-95-1
2-(2-(2-hydroxyethyl)-1,3-dioxolan-2-yl)ethanol

: 312326-54-8
(R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran

1.2: 76 percent / Bu₄NI

2.1: 97 percent / Dess-Martin periodinane

3.1: 83 percent / Bu₂BOTf / CH₂Cl₂

4.1: 85 percent / LiBH₄ / tetrahydrofuran

5.1: 99 percent / imidazole / dimethylformamide

6.1: 84 percent / EDC / CH₂Cl₂

7.1: 99 percent / FeCl₃; SiO₂ / CHCl₃

8.1: 91 percent / NaH / tetrahydrofuran / 0 °C

With 1H-imidazole; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; silica gel; iron(III) chloride; sodium hydride; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Metallation / 2.1: Oxidation / 3.1: Metallation / 4.1: Reduction / 5.1: Substitution / 6.1: Acylation / 7.1: Ring cleavage / 8.1: Cyclization;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 6506-31-6
dimethyl acetonedicarboxylate ethylene ketal

: 312326-54-8
(R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 99 percent / LiAlH₄ / tetrahydrofuran

2.1: NaH / tetrahydrofuran

2.2: 76 percent / Bu₄NI

3.1: 97 percent / Dess-Martin periodinane

4.1: 83 percent / Bu₂BOTf / CH₂Cl₂

5.1: 85 percent / LiBH₄ / tetrahydrofuran

6.1: 99 percent / imidazole / dimethylformamide

7.1: 84 percent / EDC / CH₂Cl₂

8.1: 99 percent / FeCl₃; SiO₂ / CHCl₃

9.1: 91 percent / NaH / tetrahydrofuran / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; silica gel; iron(III) chloride; sodium hydride; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: Metallation / 3.1: Oxidation / 4.1: Metallation / 5.1: Reduction / 6.1: Substitution / 7.1: Acylation / 8.1: Ring cleavage / 9.1: Cyclization;
DOI:10.1016/S0040-4039(00)01337-X