N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

Base Information

Chemical Name:N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide
CAS No.:1196452-58-0
Molecular Formula:C₂₅H₂₃BrF₂N₄O₃
Molecular Weight:545.383
Hs Code.:

Synonyms:N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

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Chemical Property of N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

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Technology Process of N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

There total 4 articles about N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 373-96-6
2,2-difluoropropanoic acid

: 1196452-57-9
(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-amine

: 1196452-58-0
N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

Guidance literature:: 2,2-difluoropropanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 7h;

(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-amine; In tetrahydrofuran; at 16 - 25 ℃; for 64h;

Reference yield:

: 1196452-56-8
(1R,2S)-2-amino-1-(6-methoxypyridin-3-yl)propan-1-ol

: 1196452-58-0
N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C

1.2: 20 h / 130 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 7 h

2.2: 64 h / 16 - 25 °C

With caesium carbonate; 1,1'-carbonyldiimidazole; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; propyl cyanide;

Reference yield:

: 1196452-55-7
tert-butyl (1R,2S)-1-hydroxy-1-(6-methoxypyridin-3-yl)propan-2-ylcarbamate

: 1196452-58-0
N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane / 2 h / 16 - 25 °C

1.2: 60 °C

2.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C

2.2: 20 h / 130 °C

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 7 h

3.2: 64 h / 16 - 25 °C

With hydrogenchloride; caesium carbonate; 1,1'-carbonyldiimidazole; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; 1,4-dioxane; propyl cyanide;