3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide

Base Information

Chemical Name:3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide
CAS No.:1196452-37-5
Molecular Formula:C₃₀H₃₃F₂N₅O₅
Molecular Weight:581.619
Hs Code.:

Synonyms:3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide

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Chemical Property of 3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide

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Technology Process of 3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide

There total 5 articles about 3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1196452-58-0
N-[(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-1-(6-methoxypyridin-3-yl)propan-2-yl]-2,2-difluoropropanamide

: 13552-21-1
2-hydroxy-butylamine

: 13939-06-5,199620-15-0
molybdenum hexacarbonyl

: 1196452-37-5
3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide

Guidance literature:: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; at 125 ℃; for 0.166667h;

Reference yield:

: 1196452-52-4
[(1S)-2-(6-methoxy-3-pyridinyl)-1-methyl-2-oxoethyl]-carbamic acid t-butyl ester

: 1196452-37-5
3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / aluminum isopropoxide / toluene / 72 h / 50 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 16 - 25 °C

2.2: 60 °C

3.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C

3.2: 20 h / 130 °C

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 7 h

4.2: 64 h / 16 - 25 °C

5.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran / 0.17 h / 125 °C

With hydrogenchloride; caesium carbonate; isopropyl alcohol; 1,1'-carbonyldiimidazole; copper(l) iodide; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); dimethylaminoacetic acid; aluminum isopropoxide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; propyl cyanide; toluene;

Reference yield:

: 1196452-56-8
(1R,2S)-2-amino-1-(6-methoxypyridin-3-yl)propan-1-ol

: 1196452-37-5
3-(5-{[(1R,2S)-2-[(2,2-difluoropropanoyl)amino]-1-(6-methoxypyridin-3-yl)propyl]oxy}-1H-indazol-1-yl)-N-(2-hydroxybutyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C

1.2: 20 h / 130 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 7 h

2.2: 64 h / 16 - 25 °C

3.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate / tetrahydrofuran / 0.17 h / 125 °C

With caesium carbonate; 1,1'-carbonyldiimidazole; copper(l) iodide; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); dimethylaminoacetic acid; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; propyl cyanide;