(S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate
CAS No.:1277192-05-8
Molecular Formula:C₂₀H₂₀BrF₂NO₃
Molecular Weight:440.285
Hs Code.:

Synonyms:(S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

Suppliers and Price of (S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

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Technology Process of (S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

There total 1 articles about (S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 479423-43-3
tert-butyl 4-bromobenzylidenecarbamate

: 86340-78-5
2,2-difluoro-1-phenyl-1-trimethylsiloxyethene

: 1277192-05-8
(S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

Guidance literature:: With (S)-3,3'-bis(9-anthracenyl)-6,6'-dimethyl-1,1'-biphenyl-2,2'-phosphate; In tetrahydrofuran; at 20 ℃; for 23h; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ol200374m

Reference yield: 100.0%

: 1277192-05-8
(S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

: 1277192-11-6
(S)-3-amino-3-(4-bromophenyl)-2,2-difluoro-1-phenylpropan-1-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h; optical yield given as %ee;
DOI:10.1021/ol200374m

Reference yield:

: 1277192-05-8
(S)-tert-butyl N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)carbamate

: 1277192-12-7
(S)-N-(1-(4-bromophenyl)-2,2-difluoro-3-oxo-3-phenylpropyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: pyridine / tetrahydrofuran / 0 - 20 °C

With pyridine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol200374m