86340-78-5

Basic information

• Product Name: Silane, [(2,2-difluoro-1-phenylethenyl)oxy]trimethyl-
• CAS NO: 86340-78-5
• Molecular Formula: C11H14F2OSi
• Molecular Weight: 228.314
• Mol File: 86340-78-5.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: Silane, [(2,2-difluoro-1-phenylethenyl)oxy]trimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, [(2,2-difluoro-1-phenylethenyl)oxy]trimethyl-(86340-78-5)
• EPA Substance Registry System: Silane, [(2,2-difluoro-1-phenylethenyl)oxy]trimethyl-(86340-78-5)

Safety Data

• Hazardous Substances Data: 86340-78-5(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 734-18-9 2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethan-1-one 
• 100-58-3 phenylmagnesium bromide 
• 1259998-89-4 2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 5908-41-8 benzoyltrimethylsilane 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 

Downstream Products

• 126115-55-7 3,3-Difluoro-2-methoxycarbonylamino-4-oxo-4-phenyl-butyric acid methyl ester 
• 495418-34-3 2,2-difluoro-3-hydroxy-1,3-diphenylbutan-1-one 
• 1150587-85-1 2,2-difluoro-2-(2-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone 
• 1150587-99-7 3-(benzyl(methyl)amino)-2,2-difluoro-1-phenylpropan-1-one 
• 1150587-91-9 2-(6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinolin-1-yl)-2,2-difluoro-1-phenylethanone 
• 1150587-87-3 2,2-difluoro-1-phenyl-2-(2-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone 
• 1150587-89-5 2,2-difluoro-1-phenyl-2-(2-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)ethanone 
• 1150587-84-0 2,2-difluoro-2-(2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)-1-phenylethanone 

Relevant articles and documents

Expedient synthesis of [18F]-labeled α-trifluoromethyl ketones

Several [18F]-labeled α-trifluoromethyl ketones have been synthesized. Reactions of 2,2-difluoro-1-aryl-1-trimethylsiloxyethenes (1a-d) with [18F]-F2 at low temperature produced [ 18F]-labeled α-trifluoromethyl

Photoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes

A mild and facile approach to construct various perfluoroketonesviaphoto-catalyzed difluoroalkylation of difluoroenoxysilanes is developed. The reaction includes a strategy of combination of two fluorine-containing functional groups, which confers the reaction with characteristics like high efficiency, mild conditions, and broad scope. A variety of fluoroalkyl halides including perfluoroalkyl iodides, bromo difluoro esters and amides can be employed as radical precursors. Control experiments indicate that a single-electron transfer pathway may be involved in the reaction.

Trifluoromethylthiolation, Trifluoromethylation, and Arylation Reactions of Difluoro Enol Silyl Ethers

This study reports a new application area of difluoro enol silyl ethers, which can be easily obtained from trifluoromethyl ketones. The main focus has been directed to the electrophilic fluoroalkylation and arylation methods. The trifluoromethylthiolation of difluoro enol silyl ethers can be used for the construction of a novel trifluoromethylthio-α,α-difluoroketone (-COCF2SCF3) functionality. The -CF2SCF3 moiety has interesting properties due to the electron-withdrawing, albeit lipophilic, character of the SCF3 group, which can be combined with the high electrophilicity of the difluoroketone motif. The methodology could also be extended to difluoro homologation of the trifluoromethyl ketones using the Togni reagent. In addition, we presented a method for transition-metal-free arylation of difluoro enol silyl ethers based on hypervalent iodines.