(2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane

Base Information

Chemical Name:(2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane
CAS No.:140661-01-4
Molecular Formula:C₂₂H₃₆N₂O₃
Molecular Weight:376.539
Hs Code.:

Synonyms:(2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane

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Technology Process of (2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane

There total 3 articles about (2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140660-63-5
(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

: 140661-01-4
(2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane

Guidance literature:: With trifluoroacetic acid; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2 a.) THF, water, 0 deg C, 4 h, b.) RT, 12 h;
DOI:10.1021/jm00088a007

Reference yield:

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 140661-01-4
(2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, diphenylphosphoryl azide / 1.) toluene, 70 deg C, 1.5 h, 2.) toluene, reflux, 72 h

2: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2 a.) THF, water, 0 deg C, 4 h, b.) RT, 12 h

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid;
DOI:10.1021/jm00088a007

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 140661-01-4
(2S,3S,5R)-2-amino-5-<<(phenylmethoxy)carbonyl>amino>-1-cyclohexyl-3-hydroxy-6-methylheptane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, diphenylphosphoryl azide / 1.) toluene, 70 deg C, 1.5 h, 2.) toluene, reflux, 72 h

2: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2 a.) THF, water, 0 deg C, 4 h, b.) RT, 12 h

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid;
DOI:10.1021/jm00088a007