N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide

Base Information

Chemical Name:N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide
CAS No.:163280-00-0
Molecular Formula:C₂₂H₁₃F₅N₂O₃S
Molecular Weight:480.415
Hs Code.:

Synonyms:N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide

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Chemical Property of N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide

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Technology Process of N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide

There total 4 articles about N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 163317-98-4
C₁₂H₇F₅N₂O

: 93-11-8
2-Naphthalenesulfonyl chloride

: 163280-00-0
N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide

Guidance literature:: C₁₂H₇F₅N₂O; 2-Naphthalenesulfonyl chloride; With pyridine; at 20 ℃;

With water; potassium hydroxide; In 1,4-dioxane; at 90 ℃; for 0.5h;
DOI:10.1248/cpb.59.1069

Reference yield:

: 163318-40-9
C₁₂H₅F₅N₂O₃

: 163280-00-0
N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium dithionite; water / tetrahydrofuran / 2.5 h / 20 °C

2.1: pyridine / 20 °C

2.2: 0.5 h / 90 °C

With pyridine; sodium dithionite; water; In tetrahydrofuran;
DOI:10.1248/cpb.59.1069

Reference yield:

: 72587-15-6
2-chloro-3-nitro-5-(trifluoromethyl)pyridine

: 163280-00-0
N-[2-(2,4-difluorophenoxy)-5-trifluoromethyl-3-pyridyl]-2-naphthalenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 20 °C / Reflux

2.1: sodium dithionite; water / tetrahydrofuran / 2.5 h / 20 °C

3.1: pyridine / 20 °C

3.2: 0.5 h / 90 °C

With pyridine; sodium dithionite; water; potassium carbonate; In tetrahydrofuran; acetone;
DOI:10.1248/cpb.59.1069