1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate

Base Information

• Chemical Name: 1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate
• CAS No.: 123477-28-1
• Molecular Formula: C₂₉H₃₄O₅
• Molecular Weight: 462.586
• Mol file: 123477-28-1.mol

Synonyms:1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate

Chemical Property of 1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate

There total 9 articles about 1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,1-Dimethylethyl (S)-5-hydroxy-3-oxo-6-(triphenylmethoxy)hexanoate (113240-61-2) → 1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate (123477-28-1)

Guidance literature:

With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃;

DOI:10.1016/S0957-4166(00)86320-X

Reference yield: 66.8%

→ 1,1-Dimethylethyl (3R,5S)-3,5-dihydroxy-6-(triphenylmethoxy)hexanoate (123477-28-1)

Guidance literature:

Reference yield:

(R)-5-Hydroxy-3-oxo-6-trityloxy-hexanoic acid tert-butyl ester (113240-61-2) → (3S,5R)-3,5-Dihydroxy-6-trityloxy-hexanoic acid tert-butyl ester (123477-28-1,130852-61-8)

Guidance literature:

With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃;

DOI:10.1016/S0957-4166(00)86320-X

upstream raw materials:

(R)-5-Hydroxy-3-oxo-6-trityloxy-hexanoic acid tert-butyl ester

methyl (R)-3-hydroxy-4-(triphenylmethyl)oxybutanoate

1,1-Dimethylethyl (S)-5-hydroxy-3-oxo-6-(triphenylmethoxy)hexanoate

t-butyl lithioacetate

Downstream raw materials:

tert-butyl 6-triphenylmethyloxy-3(R),5(S)-(4-methoxyphenyl)boranatohexanoate

tert-butyl-6-triphenylmethyloxy-3(R),5(S)-(3-nitrophenyl)boranatohexanoate

tert-butyl-6-triphenylmethyloxy-3(R),5(S)-phenylboranatohexanoate

tert-butyl-6-triphenylmethyloxy-3(R),5(S)(1-napththalenyl)boranatohexanoate