(S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Base Information

Chemical Name:(S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester
CAS No.:302600-55-1
Molecular Formula:C₄₄H₆₆N₂O₉Si
Molecular Weight:795.102
Hs Code.:

(S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Synonyms:(S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

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Chemical Property of (S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

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Technology Process of (S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

There total 6 articles about (S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2-(3-tert-butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid

: 302600-51-7
(R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester

: 302600-55-1
(S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/S0960-894X(00)00356-5

Reference yield:

: 162473-70-3
(E)-(3S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-6-phenyl-hex-5-en-3-ol

: 302600-55-1
(S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: iPr₂NEt / CH₂Cl₂ / 10 h

2.1: 130 mg / TBAF / tetrahydrofuran / 3 h

3.1: Dess-Martin periodinane / CH₂Cl₂ / 0 °C

4.1: NaH / tetrahydrofuran / 1 h / 0 °C

4.2: tetrahydrofuran / 0.33 h / 0 °C

5.1: 120 mg / PPTS / 2-methyl-propan-2-ol / 6 h / Heating

6.1: 110 mg / EDCI*HCl; DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; sodium hydride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 3.1: Dess-Martin oxidation / 4.2: Horner-Emmons reaction;
DOI:10.1016/S0040-4020(01)00339-8

Reference yield:

: (E)-(3S,4R)-3-Methoxymethoxy-4-methyl-6-phenyl-hex-5-enal

: 302600-55-1
(S)-2-(3-tert-Butoxycarbonylamino-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 1 h / 0 °C

1.2: tetrahydrofuran / 0.33 h / 0 °C

2.1: 120 mg / PPTS / 2-methyl-propan-2-ol / 6 h / Heating

3.1: 110 mg / EDCI*HCl; DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; pyridinium p-toluenesulfonate; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 1.2: Horner-Emmons reaction;
DOI:10.1016/S0040-4020(01)00339-8