5-(2-Pyridinyl)-2-thiophenecarbonyl chloride

Base Information

• Chemical Name: 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride
• CAS No.: 119082-98-3
• Molecular Formula: C10H6 Cl N O S
• Molecular Weight: 223.683
• Hs Code.: 2934999090
• European Community (EC) Number: 640-794-1
• DSSTox Substance ID: DTXSID40379883
• Wikidata: Q82169902
• Mol file: 119082-98-3.mol

Synonyms:119082-98-3;5-(2-PYRIDINYL)-2-THIOPHENECARBONYL CHLORIDE;5-(Pyridin-2-yl)thiophene-2-carbonyl chloride;5-pyridin-2-ylthiophene-2-carbonyl chloride;2-Thiophenecarbonyl chloride, 5-(2-pyridinyl)-;SCHEMBL193466;DTXSID40379883;NAWHORNTKSFUCQ-UHFFFAOYSA-N;MFCD02091501;AKOS004116957;SB67110;CS-0441863;FT-0619600;2-Thiophenecarbonylchloride,5-(2-pyridinyl)-;5-(2-Pyridinyl)thiophene-2-carbonyl chloride;5-(Pyrid-2-yl)thiophene-2-carbonyl chloride;5-(2-PYRIDINYL)-2-THIOPHENECARBONYLCHLORIDE;J-516138;5-(2-Pyridinyl)-2-thiophenecarbonyl chloride, AldrichCPR

Chemical Property of 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride

Chemical Property:

• Vapor Pressure: 1.97E-05mmHg at 25°C
• Melting Point: 142-143°C
• Boiling Point: 362.1°Cat760mmHg
• Flash Point: 172.8°C
• PSA: 58.20000
• Density: 1.365g/cm³
• LogP: 3.18910
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 222.9858627
• Heavy Atom Count: 14
• Complexity: 224

Purity/Quality:

98%min ^*data from raw suppliers

5-Pyridin-2-ylthiophene-2-carbonyl chloride 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=CC=C(S2)C(=O)Cl

Technology Process of 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride

There total 1 articles about 5-(2-Pyridinyl)-2-thiophenecarbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(pyridin-2-yl)thiophene-2-carboxylic acid (119082-97-2) → 5-(2-pyridinyl)-2-thiophenecarbonyl chloride (119082-98-3)

Guidance literature:

With thionyl chloride; In toluene;

Reference yield: 13.0%

(S)-3-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine (851882-63-8) + 5-(2-pyridinyl)-2-thiophenecarbonyl chloride (119082-98-3) → {(S)-3-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-1-yl}-(5-pyridin-2-yl-thiophen-2-yl)methanone

Guidance literature:

(S)-3-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine; 5-(2-pyridinyl)-2-thiophenecarbonyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃;

With hydrogenchloride;

Reference yield:

5-(2-pyridinyl)-2-thiophenecarbonyl chloride (119082-98-3) → N-(2-chloro-5-((((1R)-1-phenylethyl)amino)methyl)-phenyl)-5-(2-pyridinyl)-2-thiophenecarboxamide (1025771-20-3)

Guidance literature:

upstream raw materials:

5-(pyridin-2-yl)thiophene-2-carboxylic acid

Downstream raw materials:

N-(2-chloro-5-((((1R)-1-phenylethyl)amino)methyl)-phenyl)-5-(2-pyridinyl)-2-thiophenecarboxamide