119082-97-2

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-PYRIDYL)THIOPHENE-2-CARBOXYLIC ACID is used as a potent histone deacetylase (HDAC) inhibitor for its ability to modulate gene expression and influence cellular processes. As an HDAC inhibitor, it has potential applications in the treatment of various diseases, including cancer, by altering the epigenetic landscape of cells and promoting the re-expression of silenced genes.

InChI:InChI=1/C10H7NO2S/c12-10(13)9-5-4-8(14-9)7-3-1-2-6-11-7/h1-6H,(H,12,13)

Upstream product

• 124-38-9 carbon dioxide 
• 3319-99-1 2'-(2-thienyl)pyridine 
• 123784-07-6 2-(5-bromothiophen-2-yl)pyridine 
• 1003-31-2 thiophene-2-carbonitrile 

Downstream Products

• 119082-98-3 5-(2-pyridinyl)-2-thiophenecarbonyl chloride 
• 1035231-43-6 2-{3-pyridin-3-yl-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl}phenol 
• 863409-60-3 C₂₈H₂₄N₆O₃S 
• 1035232-50-8 3-{3-pyridin-3-yl-1-[(5-pyridin-2-yl-2-thienyl)carbonyl]-4,5-dihydro-1H-pyrazol-5-yl}phenol 
• 1035232-18-8 2-{5-[(5-phenyl-3-pyridin-3-yl-4,5-dihydro-1H-pyrazol-1-yl)carbonyl]-2-thienyl}pyridine 
• 1035231-54-9 C₂₄H₁₇FN₄O₂S 
• 1035231-83-4 C₂₄H₁₇FN₄O₂S 
• 1035232-28-0 C₂₄H₁₇FN₄O₂S 
• 1035230-80-8 C₂₄H₁₇FN₄O₂S 
• 1265322-53-9 (3S)-1-(2-hydroxy-2-(4-(5-(5-(pyridin-2-yl)thiophen-2-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid 

Relevant academic research and scientific papers

Coupling of Organotin Reagents with Aryl, Acyl and Heteroaryl Halides Part Two: Synthesis of Thienylpyridine Derivatives

Coupling of organotin reagent Bu3SnAr (Ar = 2- or 3-pyridyl, or 2- or 3-thienyl) with appropriately halogenated heterocyclic in the presence of PdCl(CH2Ph)(PPh3)2 leads to the corresponding thienylpyridine derivative.Functionality is tolerated on the thiophene centre, but not in the case of the corresponding pyridine analogue.The compounds Bu3SnAr were prepared by a variety of methods, giving good yield of the tri-n-butylstannylated heterocycle.Other derivatives are prepared by direct reaction with the thienylpyridine nucleus.Examples of homo-coupling of the both organotin compounds and the aryl halide are also reported.

SYNTHESIS OF 2-(2-THIENYL)PYRIDINE AND SOME OF ITS DERIVATIVES

2-(2-Thienyl)pyridine was obtained with a high yield from 2-thiophenecarbonitrile and acetylene at elevated pressure and temperature in the presence of η5-dicyclopentadienylcobalt (cobaltocene).The bromination, chlorination, nitration, carboxylation, and acetylation of 2-(2-thienyl)pyridine were studied.Oximation of 2-(5-acetyl-2-thienyl)pyridine in water-alcohol solution gave a mixture of 2-(5-methylcarbamoyl-2-thienyl)pyridine and syn-2-pyridine.