2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate

Base Information

• Chemical Name: 2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate
• CAS No.: 1425783-56-7
• Molecular Formula: C₂₁H₂₄N₂O₃Si
• Molecular Weight: 380.519
• Mol file: 1425783-56-7.mol

Synonyms:2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate

Chemical Property of 2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate

There total 2 articles about 2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + (4-chloro-1H-indol-1-yl)(phenyl)methanone (858230-84-9) + sodium isocyanate (917-61-3) → 2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate (1425783-56-7)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-BuBrettPhos; triethylamine; In toluene; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol400369n

Reference yield:

4-chloro-1H-indole (25235-85-2) + benzoyl chloride (98-88-4) → 2-(trimethylsilyl)ethyl (1-benzoyl-1H-indol-4-yl)carbamate (1425783-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere

2: triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-BuBrettPhos / toluene / 16 h / 110 °C / Inert atmosphere

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-BuBrettPhos; triethylamine; In dichloromethane; toluene;

DOI:10.1021/ol400369n

upstream raw materials:

2-(Trimethylsilyl)ethanol

(4-chloro-1H-indol-1-yl)(phenyl)methanone

sodium isocyanate

4-chloro-1H-indole