2-oxo-1,2-diphenylethyl-4-azidobenzoate

Base Information

• Chemical Name: 2-oxo-1,2-diphenylethyl-4-azidobenzoate
• CAS No.: 1401734-73-3
• Molecular Formula: C₂₁H₁₅N₃O₃
• Molecular Weight: 357.368
• Mol file: 1401734-73-3.mol

Synonyms:2-oxo-1,2-diphenylethyl-4-azidobenzoate

Chemical Property of 2-oxo-1,2-diphenylethyl-4-azidobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-oxo-1,2-diphenylethyl-4-azidobenzoate

There total 3 articles about 2-oxo-1,2-diphenylethyl-4-azidobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-azidobenzoyl chloride (14848-01-2) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 2-oxo-1,2-diphenylethyl-4-azidobenzoate (1401734-73-3)

Guidance literature:

With dmap; In dichloromethane; for 16h; Inert atmosphere;

DOI:10.1039/c8md00405f

Reference yield:

4-azidobenzoic acid (6427-66-3) → 2-oxo-1,2-diphenylethyl-4-azidobenzoate (1401734-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 5 h / 75 °C

2: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C

With pyridine; dmap; thionyl chloride; In dichloromethane;

DOI:10.1016/j.tetlet.2012.08.032

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 2-oxo-1,2-diphenylethyl-4-azidobenzoate (1401734-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite; sodium azide / water / 0.25 h / 0 - 20 °C

2: thionyl chloride / 5 h / 75 °C

3: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C

With pyridine; hydrogenchloride; dmap; thionyl chloride; sodium azide; sodium nitrite; In dichloromethane; water;

DOI:10.1016/j.tetlet.2012.08.032

upstream raw materials:

4-azidobenzoic acid

4-azidobenzoyl chloride

2-hydroxy-2-phenylacetophenone

4-amino-benzoic acid

Downstream raw materials:

2-(4-azidophenyl)-4,5-diphenyloxazole