ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate

Base Information

• Chemical Name: ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate
• CAS No.: 99197-86-1
• Molecular Formula: C₁₈H₂₅NO₄
• Molecular Weight: 319.401
• Mol file: 99197-86-1.mol

Synonyms:ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate

Chemical Property of ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate

There total 7 articles about ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ethyl 3-(piperid-4-yl)propionate (71879-55-5) + benzyl chloroformate (501-53-1,94274-21-2) → ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate (99197-86-1)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; Ambient temperature;

DOI:10.1248/cpb.34.3747

Reference yield: 53.0%

diazoacetic acid ethyl ester (623-73-4) + benzyl 4-methylene-1-piperidinecarboxylate (138163-12-9) → ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate (99197-86-1)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; para-thiocresol; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.0c05183

Reference yield:

ethyl 3-(4-pyridinyl)-(2E)-propenoate (123293-78-7) + benzyl chloroformate (501-53-1,94274-21-2) → ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate (99197-86-1)

Guidance literature:

With sodium hydrogencarbonate; In water; acetic acid; ethyl acetate;

upstream raw materials:

ethyl 3-(piperid-4-yl)propionate

benzyl chloroformate

pyridine-4-carbaldehyde

ethyl 3-(4-pyridinyl)-(2E)-propenoate

Downstream raw materials:

ethyl 4-(1-benzyloxycarbonyl-4-piperidyl)-2-oxobutyrate

1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoic acid

4-[(S)-4-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-ethoxycarbonyl-butyl]-piperidine-1-carboxylic acid benzyl ester

benzyl 3(S)-[4-(1-benzyloxycarbonyl-4-piperidyl)-1(R)-ethoxycarbonylbutyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

Refernces

• 1、 -. "Antirhinoviral heteroamine-substituted pyridazines". . . Retrieved 2008/06/13.
• 2、 Itoh,Kori,Inada,Nishikawa,Kawamatsu,Sugihara. "Synthesis and angiotensin converting enzyme-inhibitory activity of 1,5-benzothiazepine and 1,5-benzoxazepine derivatives. III". . p. 3747 - 3761. Retrieved 2007/10/02.