2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Base Information

Chemical Name:2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester
CAS No.:210631-21-3
Molecular Formula:C₆₃H₁₀₂N₄O₁₂
Molecular Weight:1107.52
Hs Code.:

2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Synonyms:2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

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Chemical Property of 2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

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Technology Process of 2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

There total 4 articles about 2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 66880-77-1
2-tetradecylhexadecanoic acid

: 210631-19-9
(R)-4-{(S)-2-[2-((2S,3R,4R,5S,6R)-3-Acetylamino-2-benzyloxy-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy)-acetylamino]-butyrylamino}-4-carbamoyl-butyric acid benzyl ester

: 210631-21-3
2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 50 ℃; for 12h;
DOI:10.1135/cccc19980590

Reference yield:

: 127528-38-5
benzyl-2-acetamino-2-deoxy-4,6-O-isopropylidene-3-O-methoxycarbonylmethyl-α-D-glucopyranoside

: 210631-21-3
2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / NaOH, H₂O / methanol / 4 h

2: 66 percent / 1-hydroxybenzotriazole monohydrate, N,N'-dicyclohexylcarbodiimide, i-Pr₂NEt / CH₂Cl₂; dimethylformamide / 1.) 0 deg C, 1 h, 2.) 0 deg C, 1 h; r.t., overnight

3: 71 percent / AcOH, H₂O / 2 h / 60 °C

4: 54 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, DMAP / dimethylformamide / 12 h / 50 °C

With dmap; sodium hydroxide; water; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1135/cccc19980590

Reference yield:

: 78604-09-8
2-(((4aR,6S,7R,8R,8aS)-7-acetamido-6-(benzyloxy)-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)acetic acid

: 210631-21-3
2-Tetradecyl-hexadecanoic acid (2R,3S,4R,5R,6S)-5-acetylamino-6-benzyloxy-4-{[(S)-1-((R)-3-benzyloxycarbonyl-1-carbamoyl-propylcarbamoyl)-propylcarbamoyl]-methoxy}-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / 1-hydroxybenzotriazole monohydrate, N,N'-dicyclohexylcarbodiimide, i-Pr₂NEt / CH₂Cl₂; dimethylformamide / 1.) 0 deg C, 1 h, 2.) 0 deg C, 1 h; r.t., overnight

2: 71 percent / AcOH, H₂O / 2 h / 60 °C

3: 54 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, DMAP / dimethylformamide / 12 h / 50 °C

With dmap; water; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1135/cccc19980590