methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate

Base Information

• Chemical Name: methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate
• CAS No.: 942589-58-4
• Molecular Formula: C₁₅H₁₆ClNO₂S
• Molecular Weight: 309.817
• Mol file: 942589-58-4.mol

Synonyms:methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate

Chemical Property of methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate

There total 1 articles about methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxypropene (116-11-0) + methyl 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylate (91076-93-6) → methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate (942589-58-4)

Guidance literature:

2-Methoxypropene; methyl 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylate; With sodium triacetoxyborohydride; acetic acid; In dichloromethane; at 20 ℃; for 48h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

trans-4-methylcyclohexanecarbonyl chloride + methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate (942589-58-4) → methyl 5-(4-chlorophenyl)-3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylate (942589-59-5)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 45 ℃; for 36h;

Reference yield:

trans-4-methylcyclohexanecarbonyl chloride + methyl 5-(4-chlorophenyl)-3-[(1-methylethyl)amino]-2-thiophenecarboxylate (942589-58-4) → methyl 5-(4-chlorophenyl)-3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylate

Guidance literature:

With triphenylphosphine; In dichloromethane; at 45 ℃; for 36h;

upstream raw materials:

2-Methoxypropene

methyl 3-amino-5-(4-chlorophenyl)-2-thiophenecarboxylate

Downstream raw materials:

methyl 5-(4-chlorophenyl)-3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-2-thiophenecarboxylate