(1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde

Base Information

Chemical Name:(1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde
CAS No.:931095-26-0
Molecular Formula:C₃₁H₄₄O₆Si
Molecular Weight:540.772
Hs Code.:

Synonyms:(1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde

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Chemical Property of (1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde

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Technology Process of (1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde

There total 2 articles about (1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 931095-25-9
(1S)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetic acid methyl ester

: 931095-26-0
(1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 3h;
DOI:10.1021/ol0630189

Reference yield:

: (1S)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetic acid

: 931095-26-0
(1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 180 mg / toluene; methanol; hexane / 0.17 h / 20 °C

2: 93 percent / DIBAL-H / CH₂Cl₂; toluene / 3 h / -78 °C

With diisobutylaluminium hydride; In methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ol0630189

Reference yield: 91.0%

: 931095-26-0
(1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde

: 1779-49-3
Methyltriphenylphosphonium bromide

: 931095-15-7
{(1S,4S,5S,6R)-5-benzyloxy-4-[(1R)-1-(4-methoxy-benzyloxy)-allyl]-6-methoxymethyl-cyclohex-2-enyloxy}-triethylsilane

Guidance literature:: Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; for 0.0833333h; Heating;

(1R)-1-[(1S,4S,5R,6R)-6-benzyloxy-5-methoxymethyl-4-triethylsilanyloxy-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-acetaldehyde; In tetrahydrofuran; at 20 ℃; for 0.166667h;
DOI:10.1021/ol0630189