(4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine

Base Information

Chemical Name:(4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine
CAS No.:1072930-01-8
Molecular Formula:C₂₂H₁₉ClFN₃
Molecular Weight:379.864
Hs Code.:

Synonyms:(4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine

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Chemical Property of (4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine

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Technology Process of (4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine

There total 4 articles about (4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1072930-02-9
2-(4-bromo-phenyl)-6-fluoro-1-propyl-1H-benzoimidazole

: 106-47-8
4-chloro-aniline

: 1072930-01-8
(4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine

Guidance literature:: With potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In 1,4-dioxane; at 90 ℃; for 18h;

Reference yield:

: 1072928-93-8
5-fluoro-N₁-propylbenzene-1,2-diamine

: 1072930-01-8
(4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: PPA; Polyphosphoric acid (PPA) / 18 h / 200 °C

2: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 90 °C

With PPA; Polyphosphoric acid (PPA); potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane;

Reference yield:

: 446-35-5
2,4-Difluoronitrobenzene

: 1072930-01-8
(4-chloro-phenyl)-[4-(6-fluoro-1-propyl-1H-benzoimidazol-2-yl)-phenyl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran / 18 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 96 h / 20 °C

3: PPA; Polyphosphoric acid (PPA) / 18 h / 200 °C

4: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 90 °C

With PPA; Polyphosphoric acid (PPA); hydrogen; potassium carbonate; palladium diacetate; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane;