446-35-5

Basic information

• Product Name: 2,4-Difluoronitrobenzene
• Synonyms: 1-Nitro-2,4-difluorobenzene;2,4-difluoro-1-nitro-benzen;2,4-Difluronitrobenzene;Benzene, 2,4-difluoro-1-nitro-;1,3-difluoro-4-nitrobenzene;2,4-DIFLUORO-1-NITROBENZENE;2,4-DIFLUORONITROBENZENE;2,4-DIFLUORO NITROBENZEN
• CAS NO: 446-35-5
• Molecular Formula: C₆H₃F₂NO₂
• Molecular Weight: 159.09
• EINECS: 207-167-0
• Product Categories: HALIDE;Aromatic Hydrocarbons (substituted) & Derivatives;Fluorine series;alkyl Fluorine| nitro-compound
• Mol File: 446-35-5.mol
• Article Data: 28

Chemical Properties

• Melting Point: 9-10 °C(lit.)
• Boiling Point: 203-204 °C(lit.)
• Flash Point: 195 °F
• Appearance: yellow liquid
• Density: 1.451 g/mL at 25 °C(lit.)
• Vapor Density: >1 (vs air)
• Vapor Pressure: 0.331mmHg at 25°C
• Refractive Index: n20/D 1.511(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• Stability: Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
• BRN: 2048034
• CAS DataBase Reference: 2,4-Difluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluoronitrobenzene(446-35-5)
• EPA Substance Registry System: 2,4-Difluoronitrobenzene(446-35-5)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 25-36/37/38-23/24/25-20/21/22
• Safety Statements: 26-45-36/37/39-23
• RIDADR: UN 2810 6.1/PG 1
• WGK Germany: 3
• RTECS: CZ5730000
• TSCA: T
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 446-35-5(Hazardous Substances Data)

Usage

Synthesis

KF with n-Hexadecyltrimethylammonium bromide as the PTC has been shown recently to work in dimethylformamide (DMF), important owing to the low cost16 of DMF.

Chemical Properties

yellow liquid

Uses

Different sources of media describe the Uses of 446-35-5 differently. You can refer to the following data:
1. 2,4-Difluoronitrobenzene has been used in the synthesis of: 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction; (±)-horsfiline; resin-bound 2-arylaminobenzimidazoles.2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents.
2. 2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.
3. 2,4-Difluoronitrobenzene has been used in the synthesis of:2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction(±)-horsfilineresin-bound 2-arylaminobenzimidazoles

General Description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

Upstream product

• 148854-10-8 (2,4-difluorophenyl)trimethylsilane 
• 372-18-9 1,3-Difluorobenzene 
• 611-06-3 2,4-dichloronitrobenzene 
• 3115-68-2 tetrabutyl phosphonium bromide 
• 56022-38-9 triethyl-hexadecyl-phosphonium; bromide 
• 126-33-0 sulfolane 
• 81175-49-7 tetrakis(diethylamino)phosphonium bromide 
• 321-23-3 4-bromo-2-fluoronitrobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 121-73-3 3-Nitrochlorobenzene 
• 144025-03-6 2,4-difluorophenylboronic acid 
• 367-25-9 2,4-difluorophenylamine 
• 2751-90-8 tetraphenylphosphonium bromide 
• 133117-48-3 1,3-difluoro-2-trimethylsilylbenzene 

Downstream Products

• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 4920-84-7 2,4-dimethoxynitrobenzene 
• 327-92-4 1,5-difluoro-2,4-dinitrobenzene 
• 367-25-9 2,4-difluorophenylamine 
• 140381-68-6 N-(2-nitro-5-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 140381-72-2 N-(3-fluoro-4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 79291-42-2 Ethyl 3-(5-fluoro-2-nitroanilino)-1-methylpyrazole-4-carboxylate 
• 134485-96-4 1,1'-(1-nitrobenzene-2,4-diyl)bis(2-methyl-1H-imidazole) 
• 133052-65-0 4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 
• 28987-48-6 4-ethoxy-2-fluoro-1-nitrobenzene 
• 28987-44-2 5-fluoro-2-nitrophenyl ethyl ether 
• 28987-53-3 2-fluoro-1-nitro-4-phenoxy-benzene 
• 28987-52-2 4-fluoro-1-nitro-2-phenoxybenzene 

Relevant articles and documents

Inexpensive, Active KF for Nucleophilic Aromatic Displacement Reactions

The simple, and inexpensive process, of recrystallizing KF from a methanol solution by slow evaporation of the solvent, followed by drying at 100 deg C, results in a highly active form of KF.The surface area was increased 20 fold by this process.This pre-treated KF proved to be considerably more efficient as a source of fluoride ion than untreated KF in the conversion of 2,4-dichloronitrobenzene to 2,4-difluoronitrobenzene.It was observed to be more efficient than spray dried KF but was less efficient than KF supported on CaF2.The results of a kinetic analysis of the above reaction using the pre-treated KF point towards a solid-liquid interfacial mechanism.

Preparation method of fluorine-containing aryl compound

The invention relates to the field of organic synthesis, and especially relates to a preparation method of a fluorine-containing aryl compound. The invention provides a preparation method of a compound as shown in a formula 1. The preparation method comprises the following steps: fluorination reaction: reacting a compound as shown in a formula 2 with alkali metal fluoride in the presence of a phase transfer catalyst to prepare the compound as shown in the formula 1. According to the preparation method of the fluorine-containing aryl compound provided by the invention, a reaction system does not contain a solvent, the boiling point of the phase transfer catalyst is relatively high, solvent interference is avoided during rectification or short steaming after the reaction is finished, the distillation yield is high, and the product purity is good.

Novel manufacturing method of fluoro-aryl compounds and derivatives thereof

The invention relates to a novel method of manufacturing fluoro-aryl compounds and derivatives thereof, in particular, fluorobenzene and derivatives thereof. The production environment of the manufacturing method is environmentally friendly. The shortages of a conventional method are overcome through a simple and beneficial mode. Compared with the prior art, the provided method is more effective,more environmentally friendly, and more energy saving. The method is used to produce core fluorinated aromatic compounds, preferably, core fluorinated fluorobenzene. On one aspect, the invention provides a method, which is advantages in industry and uses HF and a halogenated benzene precursor to prepare fluorobenzene and hydrogen halide. Moreover, the invention provides chlorobenzene as the primary raw material to prepare fluorobenzene, which is an important material in industry, and a beneficial, unexpected and simple application of chlorobenzene. In the prior art, the provided application ofchlorobenzene is unknown.