2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride

Base Information

Chemical Name:2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride
CAS No.:1286182-86-2
Molecular Formula:C₁₃H₁₇N₃O₂*ClH
Molecular Weight:283.758
Hs Code.:

Synonyms:2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride

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Chemical Property of 2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride

Chemical Property:

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Technology Process of 2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride

There total 4 articles about 2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1286182-85-1
2-methyl-propane-2-sulfinic acid ((S)-1-{3-[5-(1-hydroxy-1-methyl-ethyl)-1,2,4-oxadiazol-3-yl]phenyl}ethyl)amide

: 1286182-86-2
2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 0 ℃; for 0.333333h;

Reference yield:

: 6136-68-1
3-acethylbenzonitrile

: 1286182-86-2
2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 75 °C

1.2: 3 h / -48 - 20 °C

1.3: 0 °C

2.1: hydroxylamine hydrochloride; triethylamine / methanol / 20 °C / Cooling with ice

3.1: potassium carbonate / 6 h / Reflux

4.1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 0 °C

With hydrogenchloride; titanium(IV) tetraethanolate; hydroxylamine hydrochloride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 1286182-82-8
N-[(1S)-1-(3-cyanophenyl)ethyl]-2-methyl-[S(R)]-2-propanesulfinamide

: 1286182-86-2
2-{3-[3-((S)-1-amino-ethyl)phenyl]-1,2,4-oxadiazol-5-yl}propan-2-ol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; triethylamine / methanol / 20 °C / Cooling with ice

2: potassium carbonate / 6 h / Reflux

3: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 0 °C

With hydrogenchloride; hydroxylamine hydrochloride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol;