3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

Base Information

Chemical Name:3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester
CAS No.:874482-36-7
Molecular Formula:C₁₅H₁₃F₆NO₄
Molecular Weight:385.263
Hs Code.:

Synonyms:3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

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Chemical Property of 3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

Chemical Property:

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Technology Process of 3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

There total 2 articles about 3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 753-90-2
trifluoroethylamine

: 122-51-0
orthoformic acid triethyl ester

: 112811-68-4
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

: 874482-36-7
3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

Guidance literature:: orthoformic acid triethyl ester; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate; With acetic anhydride; for 2h; Heating / reflux;

trifluoroethylamine; In ethanol; at 0 - 20 ℃;

Reference yield:

: 753-90-2
trifluoroethylamine

: 108-24-7
acetic anhydride

: 112811-68-4
ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate

: 874482-36-7
3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

Guidance literature:: acetic anhydride; ethyl 3-methoxy-2,4,5-trifluorobenzoylacetate; With orthoformic acid triethyl ester; for 2h; Heating / reflux;

trifluoroethylamine; In ethanol; at 0 - 20 ℃;

Reference yield:

: 874482-36-7
3-[(2,2,2-trifluoroethyl)amino]-2-(2,4,5-trifluoro-3-methoxybenzoyl)acryl acid ethyl ester

: {(2RS,6SR)-4-[3-{[(2,4-dichlorobenzyl)amino]carbonyl}-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinolin-7-yl]-2,6-dimethylpiperazin-1-yl}ethanoic acid hydroformate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2.1: sulfuric acid; water; acetic acid / Heating / reflux

3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 70 °C

4.1: acetonitrile / 50 °C

4.2: 1 h / Heating / reflux

4.3: Preparative HPLC

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

6.1: hydrogenchloride / water; acetonitrile

7.1: potassium carbonate / potassium iodide / acetonitrile / Heating / reflux

7.2: Preparative HPLC

8.1: lithium hydroxide; water / 1,4-dioxane / 20 °C

8.2: pH 3

8.3: Preparative HPLC

With hydrogenchloride; lithium hydroxide; sulfuric acid; boron trifluoride diethyl etherate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;