N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Base Information

Chemical Name:N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide
CAS No.:1264366-80-4
Molecular Formula:C₂₇H₂₆N₂O₅
Molecular Weight:458.514
Hs Code.:

Synonyms:N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

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Chemical Property of N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

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Technology Process of N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

There total 8 articles about N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1264366-66-6
C₂₇H₂₈N₂O₆

: 1264366-80-4
N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; toluene; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejoc.201001077

Reference yield:

: 1264366-61-1
4-(benzyloxycarbonyl)phenylisocyanide

: 1264366-80-4
N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; isopropyl alcohol; toluene; 1: Ugi condensation / 2: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077

Reference yield:

: 19008-43-6
benzyl 4-aminobenzoate

: 1264366-80-4
N-[(4-benzyloxycarbonyl)phenyl]-3-methyl-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / diethyl ether / 0 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: 4-methyl-morpholine; trichloromethyl chloroformate / dichloromethane / 2 h / 0 °C / Inert atmosphere

4: isopropyl alcohol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

5: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; dmap; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; trichloromethyl chloroformate; In diethyl ether; dichloromethane; isopropyl alcohol; toluene; 4: Ugi condensation / 5: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077